the effect of interleukin 28 b polymorphism on sustained virology response (svr) in patients with chronic hepatitis c
نویسندگان
چکیده
background: the effect of il 28 b polymorphism on sustained virology response (svr) in patients with hepatitis c genotype 1 varies among races.â multiple studies have shown that the svr is two or three times higher in patients with cc genotype compared to those with tt genotype. this study aims to assess the relationship between il 28 b polymorphism and svr in iranian patients. materials and methods: in a cross-sectional study, 48 patients with hepatitis c genotype 1 who underwent pcr testing six months following treatment were divided into two groups, svr positive and negative in order to compare il 28 b polymorphism.â â results: the svr rate was higher in patients who presented with high baseline alt levels, independent of il 28 b genotype (p=0.023). logistic regression analysis showed a higher svr rate in patients with cc genotype compared to tt genotype ( p =0.007, or=29.333, ci=2.558-336.387), however no significant difference was noted between tc and tt genotypes ( p =0.177, or=2.887, ci=0.618-13.496). additionally, there was a significant difference between cc and non-cc groups (tc, tt) in svr rate ( p =0.017, or=13.750, ci=1.602-118.061). a high svr rate was seen in the c group (cc, tc) when compared with the tt genotype ( p =0.036, or=4.923, ci=1.111-21.816). conclusion: this study confirms the relationship between il 28 b genotype and svr rate in the patients with hepatitis c genotype 1. it seems; il 28 b genotype could be the reasonable lab.test for treatment plan of the problematic cases of the patients with chronichepatitis c. â â â
منابع مشابه
Effect of HFE gene polymorphism on sustained virological response in patients with chronic hepatitis C and elevated serum ferritin.
CONTEXT Abnormal serum ferritin levels are found in approximately 20%-30% of the patients with chronic hepatitis C and are associated with a lower response rate to interferon therapy. OBJECTIVE To determine if the presence of HFE gene mutations had any effect on the sustained virological response rate to interferon based therapy in chronic hepatitis C patients with elevated serum ferritin. ...
متن کاملبر IL 28B ژن rs اثر پلی مورفیسم تک نوکلئوتیدی 12979860 پاسخ به درمان با پگ- اینترفرون/ریباورین در بیماران C ایرانی مبتلا به هپاتیت
Background and purpose: The standard of care treatment for infected patients with HCV is based on a combination of pegylated interferon alpha and ribavirin. Recently, the rs12979860 SNP polymorphism, located upstream of the interleukin 28B gene, was shown to be strongly associated with response to anti-HCV therapy. This study investigated the distribution of the (C/T) polymorphism with sust...
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Influence of Interleukin 28 Gene Polymorphism on Response to Therapy of Chronic Hepatitis C Virus Infection in Children
Background: Investigating predictors of response to antiHCV therapy may avoid the current expensive therapy associated with various side effects. Aim of Work: To test for the hypothesis claiming that single nucleotide polymorphism (SNP) in the IL-28B gene might affect the response to antiviral treatment. The SNP rs12979860 C>T in the IL-28B gene was assayed, and its influence on response to HCV...
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گوارشجلد ۱۵، شماره ۳، صفحات ۲۰۲-۰
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